Unusual case of coexisting large intramyometrial anterior uterine wall leiomyoma with term pregnancy.

Leiomyomas are the most common benign smooth muscle tumors of the uterus. The incidence during pregnancy ranges between 1.6 to 10%. The management of fibroids encountered during caesarean section poses a therapeutic dilemma. We present a case of giant anterior wall leiomyoma complicating term pregnancy which posed a great surgical challenge. We didn't go for myomectomy in the same setting because the patient was primigravida and leiomyoma occupied complete anterior wall of the uterus, an attempt of myomectomy could result in profuse uncontrollable bleeding.

An integrated approach of designing functionality with security for distributed cyber-physical systems.

In this work, we propose a multi-tier architectural model to separate functionality and security concerns for distributed cyber-physical systems. On the line of distributed computing, such systems require the identification of leaders for distribution of work, aggregation of results, etc. Further, we propose a fault-tolerant leader election algorithm that can independently elect the functionality and security leaders. The proposed election algorithm identifies a list of potential leader capable nodes to reduce the leader election overhead. It keeps identifying the highest potential node as the leader, whenever needed, including the situation when one has failed. We also explain the proposed architecture and its management method through a case study. Further, we perform several experiments to evaluate the system performance. The experimental results show that the proposed architectural model improves the system performance in terms of latency, average response time, and the number of real-time tasks completed within the deadline.

Wilson's disease: A new perspective review on its genetics, diagnosis and treatment.

Wilson's disease (WD) is an autosomal recessive disorder which is caused by poor excretion of copper in mammalian cells. In this review, various issues such as effective characterization of ATP7B genes, scope of gene network topology in genetic analysis, pattern recognition using different computing approaches and fusion possibilities in imaging and genetic dataset are discussed vividly. We categorized this study into three major sections: (A) WD genetics, (B) diagnosis guidelines and (3) treatment possibilities. We addressed the scope of advanced mathematical modelling paradigms for understanding common genetic sequences and dominating WD imaging biomarkers. We have also discussed current state-of-the-art software models for genetic sequencing. Further, we hypothesized that involvement of machine and deep learning techniques in the context of WD genetics and image processing for precise classification of WD. These computing procedures signify changing roles of various data transformation techniques with respect to supervised and unsupervised learning models.

Atypical synophthalmos with arhinencephaly unilateralis.

This article describes a rare case of a 4-month-old infant with atypical synophthalmos with ipsilateral arhinencephaly unilateralis, ethmoid sinus, and lacrimal apparatus and brain abnormalities--diagnosed on the basis of the clinical picture and imaging findings.

Orbital space-occupying lesions in Indian children.

PURPOSE: To present a review of all patients younger than 16 years who presented to us with orbital space-occupying lesions. METHODS: Retrospective case study. RESULTS: We analyzed the records of 119 children younger than 16 years of age who had presented to us with proptosis during the 10-year study period. Myogenic tumors were the most common lesion seen (24%), followed by metastatic and secondary orbital tumors (17%), vasculogenic lesions (15%), cystic lesions (10%), inflammatory lesions simulating tumors (7.5%), optic nerve and meningeal tumors (7.5%), peripheral nerve tumors (5%), lacrimal fossa lesions (4%), lymphoid tumors and leukemias (2.5%), primitive neuroectodermal tumors (3%), and others (2.5%). CONCLUSION: We analyzed the profile of orbital lesions that underwent surgical procedures and were proven histopathologically. We found 63 malignancies among the 119 cases, for a malignancy rate of 53%. Orbital rhabdomyosarcoma and retinoblastoma with orbital spread were the most common causes of proptosis among the children.

Fibrous histiocytoma of the lacrimal gland.

Fibrous histiocytoma, a primary mesenchymal tumor of the orbit, is known to arise from various ocular and adnexal tissues. We are unable to find a published report of this tumor originating from the lacrimal gland. We report a case of a benign fibrous histiocytoma of the lacrimal gland in an 11 year old girl who presented with painless, progressive eyelid swelling and mild proptosis. Imaging studies revealed a discrete mass in the lacrimal gland region. The tumor was completely excised by anterolateral orbitotomy. Light microscopy showed a spindle cell tumor arising from the lacrimal gland. The tumor cells were arranged in a characteristic storiform (cartwheel) pattern with no pleomorphism or mitotic figures. Immunohistochemically, the tumor cells were focally positive for CD-68 and negative for S-100, smooth muscle actin, vimentin, and CD-34, which ruled out neurofibroma, leiomyoma, solitary fibrous tumor, and hemangiopericytoma. Based on these features, a diagnosis of benign fibrous histiocytoma was made.

Atypical presentations of orbital cysticercosis.

We describe three patients with orbital cysticercosis who presented with atypical clinical or radiologic features previously unreported. All three patients had a cyst with a scolex on imaging studies. After 6 weeks of treatment, all three had almost complete resolution of their features.